TY  - Type of reference 
TI  - Scale change between organoid and organ applied to the treatment of severe diseases 
AU  - David Vauris 
AU  - Jean Claude André 
AB  - Bio-printing is a principle of additive manufacturing in which living cells can be printed or arranged in an organized manner in 3 dimensions. This technique could be useful in the manufacture of functional organs (and which could for example replace deficient organs in sick people) as soon as the locks related to the good development of these organs are unlocked. However, it can already be used to understand the effects of anti-carcinogenic substances on a healthy or malignant cell cluster (organoids). This work highlights the influence of certain parameters on the desired cell death. For example, the shape of the cluster, the diffusion of the anticarcinogen and its natural elimination over time largely influence the amount of cells remaining over time. Thus, the behavior at the microscopic scale (of the organoid) could be studied numerically from different angles while the passage to the macroscopic scale was only possible with simplifications (2-dimensional system, non-proliferation), but which allow to compare two important parameters, the natural elimination of the anticarcinogen with the cell disappearance. Thus, the hierarchy of chemotherapy chemicals resulting from work with organoids, in a logic of personalized medicine, can be challenged by other effects that cannot be taken into account on these small bio-constructs. 
DO  - 10.21494/ISTE.OP.2023.0989 
JF  - Entropy: Thermodynamics – Energy – Environment – Economy  
KW  - Bio-printing,  organoids,  Additive Manufacturing,  mathematical modelling,  cancer,  scale up, Bio-printing,  organoïdes,  Fabrication additive,  modélisation mathématique,  cancer,  changement d’échelle,  
L1  - https://openscience.fr/IMG/pdf/iste_entropie23v4n1_2.pdf 
LA  - en 
PB  - ISTE OpenScience 
DA  - 2023/06/12 
SN  - 2634-1476 
TT  - Changement d’échelle entre organoïde et organe appliqué au traitement de maladies graves 
UR  - https://openscience.fr/Scale-change-between-organoid-and-organ-applied-to-the-treatment-of-severe 
IS  - Issue 1 
VL  - 4 
ER  -