@ARTICLE{10.21494/ISTE.OP.2023.0989, 

TITLE={Scale change between organoid and organ applied to the treatment of severe diseases}, 
  
AUTHOR={David Vauris, Jean Claude André, }, 
	
JOURNAL={Entropy: Thermodynamics – Energy – Environment – Economy }, 
	
VOLUME={4}, 

NUMBER={Issue 1}, 
	
YEAR={2023}, 

URL={https://openscience.fr/Scale-change-between-organoid-and-organ-applied-to-the-treatment-of-severe}, 
	
DOI={10.21494/ISTE.OP.2023.0989}, 
	
ISSN={2634-1476}, 
	
ABSTRACT={Bio-printing is a principle of additive manufacturing in which living cells can be printed or arranged in an organized manner in 3 dimensions. This technique could be useful in the manufacture of functional organs (and which could for example replace deficient organs in sick people) as soon as the locks related to the good development of these organs are unlocked. However, it can already be used to understand the effects of anti-carcinogenic substances on a healthy or malignant cell cluster (organoids). This work highlights the influence of certain parameters on the desired cell death. For example, the shape of the cluster, the diffusion of the anticarcinogen and its natural elimination over time largely influence the amount of cells remaining over time. Thus, the behavior at the microscopic scale (of the organoid) could be studied numerically from different angles while the passage to the macroscopic scale was only possible with simplifications (2-dimensional system, non-proliferation), but which allow to compare two important parameters, the natural elimination of the anticarcinogen with the cell disappearance. Thus, the hierarchy of chemotherapy chemicals resulting from work with organoids, in a logic of personalized medicine, can be challenged by other effects that cannot be taken into account on these small bio-constructs.}}