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Vol 4 - Issue 1

Entropy: Thermodynamics – Energy – Environment – Economy

List of Articles

Scale change between organoid and organ applied to the treatment of severe diseases
David Vauris, Jean Claude André

Bio-printing is a principle of additive manufacturing in which living cells can be printed or arranged in an organized manner in 3 dimensions. This technique could be useful in the manufacture of functional organs (and which could for example replace deficient organs in sick people) as soon as the locks related to the good development of these organs are unlocked. However, it can already be used to understand the effects of anti-carcinogenic substances on a healthy or malignant cell cluster (organoids). This work highlights the influence of certain parameters on the desired cell death. For example, the shape of the cluster, the diffusion of the anticarcinogen and its natural elimination over time largely influence the amount of cells remaining over time. Thus, the behavior at the microscopic scale (of the organoid) could be studied numerically from different angles while the passage to the macroscopic scale was only possible with simplifications (2-dimensional system, non-proliferation), but which allow to compare two important parameters, the natural elimination of the anticarcinogen with the cell disappearance. Thus, the hierarchy of chemotherapy chemicals resulting from work with organoids, in a logic of personalized medicine, can be challenged by other effects that cannot be taken into account on these small bio-constructs.

Artisanal Wind Turbine for Renewable Energy Education
L. A.Rajoharisoa, N. Randriatefison

As part of the integration of the theme of "Energy Transition" into the school curriculum, we have designed an artisanal wind turbine device, intended for teaching "renewable energy" to pupils of Première S du High School. In the first part of this article, we present the theoretical elements of the wind turbine, the second part is consecrated to the achievements of the various elements and the characteristics of the device, we expose in the last part of the results of our study, very applicable and satisfactory for students during the course and exercises.